What is Active Nitric Oxide?

It’s the body’s natural regulator for blood flow and oxygen delivery to muscle tissue.

We all know the roles of oxygen and CO2 in the human body. But less well known is the role of Active Nitric Oxide (NO). 

“Active nitric oxide” refers to the biologically active form of nitric oxide, a molecule with a crucial role in the cardiovascular system. It acts as a vasodilator, meaning it relaxes the smooth muscle in the walls of blood vessels, causing them to widen, increasing blood flow. 

This process can help improve circulation and increase the delivery of oxygen and nutrients to the body's cells and tissues — particularly during exercise. 

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For athletes, more NO can mean better performance.

Active nitric oxide levels in the blood increase during physical activity, which helps to deliver more oxygen and nutrients to the muscles. In turn, this can help improve muscle endurance and strength, and reduce the risk of muscle damage.

Active nitric oxide can also help to reduce metabolic stress in tissues, which can help reduce muscle soreness and fatigue.  

Until NNOXX, however, there’s been no way to monitor active nitric oxide. Now, trainers and athletes can use NNOXX to measure and calibrate production of active nitric oxide during exercise — something previously impossible in real time.

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For trainers, NNOXX means better insight.

Personal trainers may use measurements of active nitric oxide as a training tool to monitor their clients' progress and make adjustments to their training programs. 

Using NNOXX, trainers can measure if their clients' bodies are releasing enough active nitric oxide to improve blood flow and deliver oxygen and nutrients to the muscles. If active nitric oxide levels are low, the trainer may consider adjustments to their workouts. Until now, these adjustments were elusive at best, as there was no way to measure active NO. 

Only NNOXX helps trainers track and advise during workouts, to help clients achieve peak performance.

Need even more science? Let's dig even deeper.

Need more science?

Read on.

Many forms of nitric oxide exist in the body, and not all forms are equal.  

Ordinary nitric oxide is produced by enzymes called nitric oxide synthases (NOS), which catalyze the production of nitric oxide from the amino acid L-arginine. After ordinary nitric oxide is produced, it is released from the endothelial cells in the inner lining of blood vessels. 

Exercise increases ordinary nitric oxide, which has several health benefits, like lowering blood pressure and supporting endothelial function. However, ordinary nitric oxide does not oxygenate tissue or directly enhance exercise performance. It’s also short lasting and inactive in blood. However, the body converts ordinary nitric oxide into active nitric oxide under special conditions

Active nitric oxide is released from red blood cells and is both long-lasting and active in the blood. Whereas ordinary nitric oxide helps lower blood pressure by dilating large blood vessels, active nitric oxide dilates small blood vessels to oxygenating tissues, including the brain, heart, and exercising muscles. 

NNOXX isn't simply a wearable oximeter — it's unlike anything else to date.

While a pulse oximeter can provide an indirect measure of nitric oxide's impact on the blood by measuring the blood oxygen saturation level, it can’t measure nitric oxide directly. Plus, interpretation of such results would be nearly irrelevant, or even impossible, even in a lab setting. 

NNOXX instead measures active nitric oxide as you exercise, rendering a single data measurement (“personal nitric oxide”, or PNO) athletes and trainers can monitor in the moment. This allows for on the fly calibration of workouts, using NNOXX’s mobile dashboard.

So, NNOXX isn’t just “a wearable oximeter,” but something completely different and wholly new.

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